Our Team

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Dr. Phillip Elzer

Professor, Department of Pathobiological Sciences in the LSU School of Veterinary Medicine and the Department of Veterinary Science in the LSU AgCenter

Education:
Cornell University, Ithaca, NY, Ph.D. 1992 Immunology; Cornell University, Ithaca, NY, M.S. 1989 Immunology; Rochester Institute of Technology, Rochester, NY, B.S. 1986, Biology, Rochester Institute of Technology, Rochester, NY, A.S., 1984, Biology

Research:
Dr. Elzer’s research involves multivalent vaccines for brucellosis, tuberculosis, Johne’s disease, and pseudorabies and models for infectious diseases including spongiform encephalopathies such as Mad Cow Disease.

Selected Publications:
Edmonds, M.D., L.E. Samartino, P.G. Hoyt, S.D. Hagius, J.V. Walker, F.M. Enright, G.G. Schurig and P.H. Elzer. (2001). Oral vaccination of sexually mature pigs with Brucella abortus vaccine strain RB51. Am J Vet Res 62(8):1328-1331.

Edmonds, M.D., A. Cloeckaert, N.J. Booth, W.T. Fulton, S.D. Hagius, J.V. Walker, and P.H. Elzer. (2001). Attenuation of a Brucella abortus mutant lacking a major 25 kDa outer membrane protein (Omp 25) in cattle. Am J Vet Res 62(9):1461-1466.

Roop, R.M., II, R.W. Phillips, S.D. Hagius, J.V. Walker, N.J. Booth, W.T. Fulton, M.D. Edmonds, and P.H. Elzer. (2001) Reexamination of the role of the Brucella melitensis HtrA stress response protease in virulence in pregnant goats. Vet Microbiol 82(1):91-95.

Edwards, J.F., D.S. Davis, T.J. Roffe, F. Ramiro-Ibanez, and P.H. Elzer. (2001) Fushobacteriosis in captive, wild-caught pronghorn antelope (Antilocapra americana). Vet Pathol 38(5):549-552.

Kabagambe, E.K., P.H. Elzer, J.P. Geaghan, J. Opuda-Asibo, D.T. Scholl, and J.E. Miller. (2001). Risk factors for Brucella seropositivity in goat herds in eastern and western Uganda. Prev Vet Med 52(2):91-108.

Elzer, P.H. Coordinator: Brucella abortus and B. melitensis. IN: Perry, B.D., McDermott, J.J., Randolph, T.F., Sones, K.R., and Thornton, P.K. (2002). Investing in Animal Research to Alleviate Poverty. International Livestock Research Institute (ILRI), Nairobi, Kenya.

Cook, W.E., E.S. Williams, E.T. Thorne, T.J. Kreeger, G. Stout, K. Bardsley, H. Edwards, G.G. Schurig, L.A. Colby, F.M. Enright and P.H. Elzer. (2002) Brucella abortus strain RB51 vaccination in elk. I. Efficacy of reduced dosage. J Wildl Dis 38(1):18-26.

Kreeger, T.J., W.E. Cook, W.H. Edwards, P.H. Elzer, and S.C. Olsen. (2002) Brucella abortus strain RB51 vaccination in elk. II. Failure of high dosage to prevent abortion. J. Wildl Dis 38(1): 27-31.

DelVecchio, V.G., V. Kapatral, R.J. Redkar, G. Patra, C. Mujer, T. Los, N. Ivanova, I. Anderson, A. Bhattacharayya, A. Lykidis, G. Reznik, L. Jablonski, N. Larsen, M. D'Souza, A. Bernal, M. Mazur, E. Goltsman, E. Selkov, P.H. Elzer, S. Hagius, D. O'Callaghan, J. Letesson, R. Haselkorn, N. Kyrpides, and R. Overbeek. (2002) The genome sequence of the facultative intracellular pathogen Brucella melitensis. PNAS 99(1):443-448.

Yokum, T.S., R.P. Hammer, M.L. McLaughlin, and P.H. Elzer. (2002) Peptides with indirect and in vivo activity against an intracellular pathogen: selective lysis of infected macrophages. J Pept Res 59(1): 9-17.

Edmonds, M.E., A. Cloeckaert, and P.H. Elzer. (2002). Brucella species lacking the major outer membrane protein Omp25 are attenuated in mice and protect against Brucella melitensis and Brucella ovis. Vet Microbiol 88(3):205-221.

Murphy, E.A., G.T. Robertson, M. Parent, S.D. Hagius, R.M. Roop, P.H. Elzer, and C.L Baldwin. (2002). Major histocompatibility complex class I and II expression on macrophages containing a virulent strain of Brucella abortus measured using green fluorescent protein-expressing brucellae and flow cytometry. Immunol Med Microbiol 33(3):191-200.

Parent, M, B.H. Bellaire, E.A. Murphy, R.M. Roop II, P.H. Elzer, and C.L. Baldwin. (2002). Brucella abortus siderophore 2,3-dihydroxybenzoic acid (DHBA) facilitates intracellular survival of the bacteria. Microb Pathog 32(5):239-248.

Edmonds, M.D., A. Cloeckaert, S.D. Hagius, L.E. Samartino, W.T. Fulton, J.V. Walker, F.M. Enright, N.J. Booth, and P.H. Elzer. (2002). Pathogenicity and protective activity in pregnant goats of a Brucella melitensis DOmp 25 deletion mutant. Res Vet Sci. 72(3):235-239.

Wagner, M.A., M. Eschenbrenner, T. A. Horn, J.A. Kraycer, C. V. Mujer, S. D. Hagius, P.H. Elzer, and V. G. DelVecchio. (2002) Global analysis of the Brucella melitensis proteome: Identification of proteins expressed in laboratory-grown culture. Proteomics 2(8):1047-1060.

Eschenbrenner, M., M.A. Wagner, T.A. Horn, J.A. Kraycer, C.V. Mujer, S.D. Hagius, P.H. Elzer, and V.G. DelVecchio. (2002) Comparative proteome analysis of Brucella melitensis vaccine strain Rev 1 and a virulent strain, 16M. J Bacteriol 184(18):4962-4970.

Olsen, S.C., P.H. Elzer. (2002) Wildlife Vaccines: The Promise and the Perils. ed. T. Kreeger. Brucellosis in Elk and Bison in the Greater Yellowstone Area. 38-42.

Chirgwin, S.R., P.H. Elzer, S.U. Coleman, J. M. Nowling, S.D. Hagius, M.D. Edmonds, and T.R. Klei. (2002) Infection outcome and cytokine gene expression in Brugia pahangi-infected gerbils (Meriones unguiculatus) sensitized with Brucella abortus. Infect Immun 70(11):5938-5945.

Elzer, P.H., J. Smith, T. Roffe, T. Kreeger, J. Edwards, and D. Davis. (2002). Evaluation of Brucella abortus Strain RB51 and Strain 19 in Pronghorn Antelope. Ann NY Acad Sci 969:102-105.

Mujer, C.V., M.A.Wagner, M. Eschenbrenner, T.A. Horn, J.A. Kraycer, R. Redkar, S. Hagius, P. Elzer, and V.G. DelVecchio. (2002) Global Analysis of Brucella melitensis proteomes. Ann NY Acad Sci 969:97-101.

Elzer, P.H., S.D. Hagius, D.S.Davis, V.G. DelVecchio, and F.M. Enright. (2002). Characterization of the caprine model for ruminant brucellosis. Vet Microbiol 90(1-4):425-431.

DelVecchio, V.G., V. Kapatral, P.H. Elzer, G. Patra, and C. Mujer. (2002). The genome of Brucella melitensis. Vet Microbiol 90(1-4):587-592.

Davis, D.S. and P.H. Elzer. (2002). Brucella Vaccines in Wildlife. Vet Microbiol 90(1-4): 533-544.

DelVecchio, V.G., M.A. Wagner, M. Eschenbrenner, T.A. Horn, J.A. Kraycer, F.Estock, P.H. Elzer, and C. V. Mujer. (2002). Brucella Proteomes - A Review. Vet Microbiol 90(1-4):593-603.

Cloeckaert, A., N. Vizcaino, J. Y. Paquet, R. A. Bowden, and P.H. Elzer. (2002). Major outermembrane proteins of Brucella spp.: Past, Present, and Future. Vet Microbiol 90(1-4):229-247.

Colby, L, G.G. Schurig, and P.H. Elzer, (2002) An indirect ELISA to detect the serologic response of elk inoculated with Brucella abortus strain RB51. J Wildl Dis 38(4) 752-759.

Elzer, P.H. (2002) Brucellosis Vaccines for Twenty-First century: Research Update. National Institute for Animal Agriculture. 51-56.

Elzer, P.H, S.D. Hagius, T.J. Roffe, S. Holland and D.S. Davis. (2002). Failure of RB51 as a calfhood bison vaccine against brucellosis. Proc U.S. Anim. Health Assoc 106:183-187.

Roffe, T.J., L.C. Jones, M. Drew, K. Coffin, S. Sweeney and P.H. Elzer. (2002). Effectiveness of Brucella abortus strain 19 single calfhood vaccination in elk (Cervus elaphus). Proc U.S. Anim Health Assoc 106:203-208.

Bellaire, B.H., P.H. Elzer, C.L. Baldwin, and R.M. Roop II. (2003) Production of the siderophore 2,3-dihydroxybenzoic acid by is required for wild-type of Brucella abortus in the presence of erythritol under low iron conditions in vitro. Infect Immun 71(5):2927-2832.

Bellaire, B.H., P.H. Elzer, S.D. Hagius, J.V. Walker, C.L. Baldwin, and R.M. Roop II. (2003) Genetic organization and iron responsive regulation of the Brucella abortus 2,3-hydroxybenzoic acid biosynthesis operon, a cluster of genes required for wild-type virulence in pregnant cattle. Infect Immun 71(4):1794-1803.

Elzer, P.H. (2003) History and Future of Brucellosis Vaccine Development, Applications of Genomics and Proteomics for Analysis of Bacterial Biological Warfare Agents. (2003) V.G. DelVecchio and V. Krcmery (eds.). IOS Press, Amsterdam 352:123-127.

Tsoktouridis, G., Merz, C.A., Manning, S.P., Giovagnoli-Kurtz, R., Williams, L.E., Mujer, C.V., Hagius, S., Elzer, P.H., Redkar, R.J., Patra, G., and V.G. DelVecchio. (2003). Molecular characterization of Brucella abortus chromosome II recombination J. Bacteriol. 185(20):6130-6138.

Elzer, P.H., D.S. Davis, D. Evans, B. Martin, S. Olsen, J. Rhyan, and G. Schurig (2003) Review of Brucella vaccine research in bison and elk. Proc U.S. Anim. Health Assoc 107:183-187.

Elzer, P.H. and S.D. Hagius (2003) Scientists help in search for vaccines to protect people from germ warfare. Louisiana Agriculture, Fall:47.

Elzer, P.H. (2003) Brucella species as potential biological weapons. CBRMTS-Industry III, Chemical, biological, and radiological terrorism, Applied Science and Analysis, Inc 98:1,10-11.